Human Immunocompetent Model of Neuroendocrine Liver Metastases Recapitulates Patient-Specific Tumour Microenvironment

Human Immunocompetent Model of Neuroendocrine Liver Metastases Recapitulates Patient-Specific Tumour Microenvironment

Neuroendocrine liver metastases (LM-NEN) develop in a considerable proportion of patients with gastroenteropancreatic neuroendocrine neoplasms. There is a paucity of experimental models that accurately recapitulate this complex metastatic human liver microenvironment precluding scientific and clinic...

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Bibliographic Details
Main Authors: Ewald Jan Doornebal, Nicola Harris, Antonio Riva, Ravi Jagatia, Michail Pizanias, Andreas Prachalias, Krishna Menon, Melissa Preziosi, Ane Zamalloa, Rosa Miquel, Yoh Zen, Michael Robert Orford, Simon Eaton, Nigel Heaton, John Ramage, Elena Palma, Rajaventhan Srirajaskanthan, Shilpa Chokshi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
tissue slices
neuroendocrine liver metastases
ex vivo model
soluble immunomodulators
immune checkpoint receptor
tumour modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.909180/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.909180/full

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