Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failure

Deep spatial-omics analysis of Head & Neck carcinomas provides alternative therapeutic targets and rationale for treatment failure

Abstract Immune checkpoint inhibitor (ICI) therapy has had limited success (<30%) in treating metastatic recurrent Head and Neck Oropharyngeal Squamous Cell Carcinomas (OPSCCs). We postulate that spatial determinants in the tumor play a critical role in cancer therapy outcomes. Here, we describe...

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Bibliographic Details
Main Authors: Andrew Causer, Xiao Tan, Xuehan Lu, Philip Moseley, Siok M. Teoh, Natalie Molotkov, Margaret McGrath, Taehyun Kim, Peter T. Simpson, Christopher Perry, Ian H. Frazer, Benedict Panizza, Rahul Ladwa, Quan Nguyen, Jazmina L. Gonzalez-Cruz
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00444-2

Internet

https://doi.org/10.1038/s41698-023-00444-2

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