ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently established that in vivo apoC-III predomin...

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Bibliographic Details
Main Authors: Bastian Ramms, Sohan Patel, Chelsea Nora, Ariane R. Pessentheiner, Max W. Chang, Courtney R. Green, Gregory J. Golden, Patrick Secrest, Ronald M. Krauss, Christian M. Metallo, Christopher Benner, Veronica J. Alexander, Joseph L. Witztum, Sotirios Tsimikas, Jeffrey D. Esko, Philip L.S.M. Gordts
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Journal of Lipid Research
Subjects:
lipid metabolism
apolipoprotein C-III
apolipoprotein E
triglyceride-rich lipoprotein clearance
fatty acids
lipase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322331

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http://www.sciencedirect.com/science/article/pii/S0022227520322331

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