Chemometric technique for the optimization of chromatographic system: Simultaneous HPLC determination of Rosuvastatin, Telmisartan, Ezetimibe and Atorvastatin used in combined cardiovascular therapy

Chemometric technique for the optimization of chromatographic system: Simultaneous HPLC determination of Rosuvastatin, Telmisartan, Ezetimibe and Atorvastatin used in combined cardiovascular therapy

Developed and optimized a validated isocratic reverse phase HPLC separation of Rosuvastatin, Telmisartan, Ezetimibe and Atorvastatin in pharmaceutical preparation using response surface methodology. The separation was carried out by using phenomenex C18 column (15 cm × 4.6 mm id, 5 μm particle size)...

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Bibliographic Details
Main Authors: V. Sree Janardhanan, R. Manavalan, K. Valliappan
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Arabian Journal of Chemistry
Subjects:
Atorvastatin
Central composite design
Derringer's desirability function
Ezetimibe
Rosuvastatin
Telmisartan
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535212000470

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http://www.sciencedirect.com/science/article/pii/S1878535212000470

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