Severity of SARS-CoV-2 infection is associated with high numbers of alveolar mast cells and their degranulation

Severity of SARS-CoV-2 infection is associated with high numbers of alveolar mast cells and their degranulation

BackgroundThe systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (e.g., deep vein thrombosis) and the inflammatory response post-infection....

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Bibliographic Details
Main Authors: Olga Krysko, Joshua H. Bourne, Elena Kondakova, Elena A. Galova, Katharine Whitworth, Maddy L. Newby, Claus Bachert, Harriet Hill, Max Crispin, Zania Stamataki, Adam F. Cunningham, Matthew Pugh, Abdullah O. Khan, Julie Rayes, Maria Vedunova, Dmitri V. Krysko, Alexander Brill
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
COVID-19
mast cells
protease
LUVA cells
von Willebrand factor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.968981/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.968981/full

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