Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39

Abstract Pharmacologic depletion of RNA-binding motif 39 (RBM39) using aryl sulfonamides represents a promising anti-cancer therapy but requires high levels of the adaptor protein DCAF15. Consequently, novel approaches to deplete RBM39 in an DCAF15-independent manner are required. Here, we uncover t...

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Bibliographic Details
Main Authors: Sébastien Campagne, Daniel Jutzi, Florian Malard, Maja Matoga, Ksenija Romane, Miki Feldmuller, Martino Colombo, Marc-David Ruepp, Frédéric H-T. Allain
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40254-5

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https://doi.org/10.1038/s41467-023-40254-5

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