Exploring the impact of PEGylation on pharmacokinetics: a size-dependent effect of polyethylene glycol on prostate-specific membrane antigen inhibitors

Exploring the impact of PEGylation on pharmacokinetics: a size-dependent effect of polyethylene glycol on prostate-specific membrane antigen inhibitors

Abstract Background Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer-related deaths in men. Prostate-specific membrane antigen (PSMA) as a target has gained increasing attention. This research aims to investigate and understand how altering size of PEG impacts...

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Bibliographic Details
Main Authors: Yang Liu, Li Xia, Haiyang Li, Ping Cai, Sufan Tang, Yue Feng, Guangfu Liu, Yue Chen, Nan Liu, Wei Zhang, Zhijun Zhou
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:EJNMMI Research
Subjects:
Prostate-specific membrane antigen (PSMA)
Prostate cancer (PCa)
Polyethylene glycol (PEG)
LNCaP
Micro-PET/CT
Online Access:https://doi.org/10.1186/s13550-024-01071-z

Internet

https://doi.org/10.1186/s13550-024-01071-z

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