Age-dependent degeneration of an identified adult leg motor neuron in a Drosophila SOD1 model of ALS

Age-dependent degeneration of an identified adult leg motor neuron in a Drosophila SOD1 model of ALS

Mutations in superoxide dismutase 1 (SOD1) cause familial amyotrophic lateral sclerosis (ALS) in humans. ALS is a neurodegenerative disease characterized by progressive motor neuron loss leading to paralysis and inevitable death in affected individuals. Using a gene replacement strategy to introduce...

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Bibliographic Details
Main Authors: Anthony Agudelo, Victoria St. Amand, Lindsey Grissom, Danielle Lafond, Toni Achilli, Asli Sahin, Robert Reenan, Geoff Stilwell
Format: Article
Language:English
Published: The Company of Biologists 2020-10-01
Series:Biology Open
Subjects:
als
superoxide dismutase
drosophila disease model
neurodegeneration
neuromuscular junction
Online Access:http://bio.biologists.org/content/9/10/bio049692

Internet

http://bio.biologists.org/content/9/10/bio049692

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