Recombinant AAV genome size effect on viral vector production, purification, and thermostability

Recombinant AAV genome size effect on viral vector production, purification, and thermostability

Adeno-associated virus (AAV) has shown great promise as a viral vector for gene therapy in clinical applications. The present work studied the effect of genome size on AAV production, purification, and thermostability by producing AAV2-GFP using suspension-adapted HEK293 cells via triple transfectio...

Full description

Bibliographic Details
Main Authors: Nermin Ibreljic, Benjamin E. Draper, Carl W. Lawton
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapy
adeno-associated virus
viral genome titer
capsid titer
triple transfection
anion exchange chromatography
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124000044

Internet

http://www.sciencedirect.com/science/article/pii/S2329050124000044

Similar Items