Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity

Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity

Objectives: The most important toxicity of acetaminophen is hepatotoxicity. Farnesoid X-activated receptors (FXR) are one of the nuclear receptor superfamily members which have a pivotal role in the bile acid regulation. The objective of the present study was to examine the role of FXR in mediating...

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Bibliographic Details
Main Authors: Vahid Jamshidi, Seyed Ali Hashemi, azadeh Khalili, Parviz Fallah, Mohammad Mahdi Ahmadian-Attari, Leila Beikzadeh, Roham Mazloom, Parvaneh Najafizadeh, Gholamreza Bayat
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2021-11-01
Series:Avicenna Journal of Phytomedicine
Subjects:
farnesoid x-activated receptor
acetaminophen
crocus sativus
crocin
toxicity
Online Access:https://ajp.mums.ac.ir/article_18227_a040a3498c9370831602f25abe1dd88b.pdf

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