Short-term outcomes of phosphodiesterase type 5 inhibitors for fetal growth restriction: a study protocol for a systematic review with individual participant data meta-analysis, aggregate meta-analysis, and trial sequential analysis

Short-term outcomes of phosphodiesterase type 5 inhibitors for fetal growth restriction: a study protocol for a systematic review with individual participant data meta-analysis, aggregate meta-analysis, and trial sequential analysis

Abstract Background Early onset fetal growth restriction secondary to placental insufficiency can lead to severe maternal and neonatal morbidity and mortality. Pre-clinical studies and a few small randomised clinical trials have suggested that phosphodiesterase type 5 (PDE-5) inhibitors may have pro...

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Bibliographic Details
Main Authors: Jessica Liauw, Katie Groom, Wessel Ganzevoort, Christian Gluud, Christopher J. D. McKinlay, Andrew Sharp, Laura Mackay, Chirag Kariya, Ken Lim, Peter von Dadelszen, Jacqueline Limpens, Janus C. Jakobsen, the STRIDER Consortium
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Systematic Reviews
Subjects:
Fetal growth restriction
Phosphodiesterase type 5 inhibitor
Randomised clinical trial
Trial sequential analysis
Aggregate meta-analysis
Individual patient data meta-analysis
Online Access:https://doi.org/10.1186/s13643-021-01849-5

Internet

https://doi.org/10.1186/s13643-021-01849-5

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