Glutathione peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis

Glutathione peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis

Abstract Background Platinum‐based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows finite therapeutic efficacy in patients suffering from brain metastasis (BM). The intrinsic changes of BM cells, which contribute to the poor results remain unknown. M...

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Bibliographic Details
Main Authors: Wenwen Liu, Yang Zhou, Wenzhe Duan, Jing Song, Song Wei, Shengkai Xia, Yingyan Wang, Xiaohui Du, Encheng Li, Caixia Ren, Wei Wang, Qimin Zhan, Qi Wang
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Clinical and Translational Medicine
Subjects:
brain metastasis
chemotherapeutic resistance
ferroptosis
glutathione metabolism
GPX4 inhibitor
lung cancer
Online Access:https://doi.org/10.1002/ctm2.517

Internet

https://doi.org/10.1002/ctm2.517

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