CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline.

CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline.

The ubiquitin-proteolytic system controls the stability of proteins in space and time. In this study, using a temperature-sensitive mutant allele of the cul-2 gene, we show that CRL2(LRR-1) (CUL-2 RING E3 ubiquitin-ligase and the Leucine Rich Repeat 1 substrate recognition subunit) acts at multiple...

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Bibliographic Details
Main Authors: Julien Burger, Jorge Merlet, Nicolas Tavernier, Bénédicte Richaudeau, Andreas Arnold, Rafal Ciosk, Bruce Bowerman, Lionel Pintard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3610609?pdf=render

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http://europepmc.org/articles/PMC3610609?pdf=render

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