Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity

Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity

Glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be a promising therapy. Excitotoxicity is initiat...

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Bibliographic Details
Main Authors: Irina Krasil’nikova, Alexander Surin, Elena Sorokina, Andrei Fisenko, Dmitry Boyarkin, Maxim Balyasin, Anna Demchenko, Igor Pomytkin, Vsevolod Pinelis
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
insulin
glutamate excitotoxicity
cortical neuron
delayed calcium deregulation (DCD)
mitochondrial depolarization
reactive oxygen species (ROS)
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01027/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.01027/full

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