Generation of an induced pluripotent stem cell line (MUSIi015-A) from a diabetic patient carrying mutations in ZYG11A (p.L475P) and GATA6 (p.E51K)

Generation of an induced pluripotent stem cell line (MUSIi015-A) from a diabetic patient carrying mutations in ZYG11A (p.L475P) and GATA6 (p.E51K)

Two heterozygous mutations (p.L475P in ZYG11A and p.E51K in GATA6) were identified in a family with autosomal dominant diabetes. ZYG11A-p.L475P was proposed as a causative mutation because of the complete segregation with hyperglycemia and the proven pathogenic effect on beta-cell expansion. The mod...

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Bibliographic Details
Main Authors: Siriwal Suwanpitak, Chutima Chanprasert, Ratchapong Netsrithong, Nattachet Plengvidhya, Pa-thai Yenchitsommanus, Methichit Wattanapanitch, Prapaporn Jungtrakoon Thamtarana
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Stem Cell Research
Subjects:
Familial diabetes of the adulthood
Autosomal dominant diabetes
ZYG11A
GATA6
iPSC
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122002203

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http://www.sciencedirect.com/science/article/pii/S1873506122002203

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