Synthesis and preliminary cytotoxicity evaluation of water soluble pentacyclic triterpenoid phosphonates

Synthesis and preliminary cytotoxicity evaluation of water soluble pentacyclic triterpenoid phosphonates

Abstract Synthesis, solubility and cytotoxicity evaluation of anionic phosphonates derived from betulin, betulinic acid, oleanolic acid and ursolic acid is reported. Phosphonate moieties were successfully installed at terpenoid C28 by carboxylic acid deprotonation/alkylation sequence using (dimethox...

Full description

Bibliographic Details
Main Authors: Jevgeņija Lugiņina, Vladislavs Kroškins, Rihards Lācis, Elza Fedorovska, Öznur Demir, Arita Dubnika, Dagnija Loca, Māris Turks
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Pentacyclic triterpenoids
Phosphonates
Cytotoxicity
Aqueous solubility
Online Access:https://doi.org/10.1038/s41598-024-76816-w

Internet

https://doi.org/10.1038/s41598-024-76816-w

Similar Items