Identify potential driver genes for PAX-FOXO1 fusion-negative rhabdomyosarcoma through frequent gene co-expression network mining

Identify potential driver genes for PAX-FOXO1 fusion-negative rhabdomyosarcoma through frequent gene co-expression network mining

BackgroundRhabdomyosarcoma (RMS) is a soft tissue sarcoma usually originated from skeletal muscle. Currently, RMS classification based on PAX–FOXO1 fusion is widely adopted. However, compared to relatively clear understanding of the tumorigenesis in the fusion-positive RMS, little is known for that...

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Bibliographic Details
Main Authors: Xiaohui Zhan, Yusong Liu, Asha Jacob Jannu, Shaoyang Huang, Bo Ye, Wei Wei, Pankita H. Pandya, Xiufen Ye, Karen E. Pollok, Jamie L. Renbarger, Kun Huang, Jie Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
fusion-negative RMS (FN-RMS)
fusion-positive RMS (FP-RMS)
frequent co-expression network (fGCN)
copy number alteration
upstream regulator
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1080989/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1080989/full

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