Sulfadiazine Plus Pyrimethamine Therapy Reversed Multiple Behavioral and Neurocognitive Changes in Long-Term Chronic Toxoplasmosis by Reducing Brain Cyst Load and Inflammation-Related Alterations

Sulfadiazine Plus Pyrimethamine Therapy Reversed Multiple Behavioral and Neurocognitive Changes in Long-Term Chronic Toxoplasmosis by Reducing Brain Cyst Load and Inflammation-Related Alterations

Toxoplasma gondii infects one-third of the world population. For decades, it has been considered a silent lifelong infection. However, chronically T. gondii-infected persons may present psychiatric and neurocognitive changes as anxiety, depression, and memory loss. In a model of long-term chronic in...

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Bibliographic Details
Main Authors: Barrios Leda Castaño, Andrea Alice Silva, Lina L Hernandez-Velasco, Ana Paula Da Silva Pinheiro, Daniel Gibaldi, José Roberto Mineo, Neide Maria Silva, Joseli Lannes-Vieira
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
Toxoplasma gondii
anxiety
depression
hyperactivity
memory loss
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.822567/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.822567/full

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