Differential regulatory effects of the N-terminal region in SYK-fusion kinases reveal unique activation-inducible nuclear translocation of ITK-SYK

Differential regulatory effects of the N-terminal region in SYK-fusion kinases reveal unique activation-inducible nuclear translocation of ITK-SYK

Abstract ITK-SYK and TEL-SYK (also known as ETV6-SYK) are human tumor-causing chimeric proteins containing the kinase region of SYK, and the membrane-targeting, N-terminal, PH-TH domain-doublet of ITK or the dimerizing SAM-PNT domain of TEL, respectively. ITK-SYK causes peripheral T cell lymphoma, w...

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Bibliographic Details
Main Authors: Abdulrahman Hamasy, Alamdar Hussain, Dara K. Mohammad, Qing Wang, Manuela Gustafsson Sfetcovici, Beston F. Nore, Abdalla J. Mohamed, Rula Zain, C. I. Edvard Smith
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-83962-8

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https://doi.org/10.1038/s41598-024-83962-8

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