An investigation into anti-proliferative effects of microRNAs encoded by the miR-106a-363 cluster on human carcinoma cells and keratinocytes using microarray profiling of miRNA transcriptomes.

An investigation into anti-proliferative effects of microRNAs encoded by the miR-106a-363 cluster on human carcinoma cells and keratinocytes using microarray profiling of miRNA transcriptomes.

Transfection of human oral squamous carcinoma cells (clone E10) with mimics for unexpressed miR-20b or miR-363-5p, encoded by the miR-106a-363 cluster (miR-20b, miR-106a, miR-363-3p or miR-363-5p), caused 40-50% decrease in proliferation. Transfection with mimics for miR-18a or miR-92a, encoded by t...

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Bibliographic Details
Main Authors: Cuong eKhuu, Anne-Marthe eJevnaker, Magne eBryne, Harald eOsmundsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Genetics
Subjects:
Cancer
EGFR
proliferation
miR-106-363
miR-106b-25
miR-363-5p
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00246/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00246/full

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