Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy

Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy

Objective: Oridonin (Ori) is a diterpene compound that has multiple biological properties. Here, our study was conducted to observe the therapeutic effect of Ori on depression as well as to uncover the mechanism.Methods: Lipopolysaccharide (LPS)-induced depression models were established both in C57...

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Bibliographic Details
Main Authors: Chunyan Li, Yuehua Zhu, Yuanyuan Wu, Meiyuan Fu, Yiling Wu, Yuehong Wu, Yinger Qiu, Hui Zhang, Mingxing Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Medicine
Subjects:
Oridonin
depression
autophagy
NLRP3 inflammasome
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.813047/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.813047/full

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