Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1

Objective: The distal dying-back of the longest nerve fibres is a hallmark of diabetic neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) may contribute to this neurodegenerative process. We hypothesised that energy supplementation via glycolysis and/or mitochon...

Descrizione completa

Dettagli Bibliografici
Autori principali: Mohamad-Reza Aghanoori, Vicky Margulets, Darrell R. Smith, Lorrie A. Kirshenbaum, Daniel Gitler, Paul Fernyhough
Natura: Articolo
Lingua:English
Pubblicazione: Elsevier 2021-07-01
Serie:Molecular Metabolism
Soggetti:
Accesso online:http://www.sciencedirect.com/science/article/pii/S2212877821000314