Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction

Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction

Summary: Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear if stimulating fatty acid oxidation is a desirable approach to treat HF. Both immediate and chronic mal...

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Main Authors: Wei Wang, MD, PhD, Liyan Zhang, PhD, Pavan K. Battiprolu, PhD, Arata Fukushima, MD, PhD, Khanh Nguyen, BS, Kenneth Milner, BS, Abhishek Gupta, PhD, Tariq Altamimi, PhD, Nikole Byrne, BS, Jun Mori, MD, PhD, Osama Abo Alrob, PhD, Cory Wagg, Natasha Fillmore, PhD, Shao-hua Wang, MD, PhD, Dongming M. Liu, BS, Angela Fu, BS, Jenny Yinglin Lu, BS, Mary Chaves, MS, Alykhan Motani, PhD, John R. Ussher, PhD, Jeff D. Reagan, PhD, Jason R.B. Dyck, PhD, Gary D. Lopaschuk, PhD
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19300622

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http://www.sciencedirect.com/science/article/pii/S2452302X19300622

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