Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies

Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies

Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, leads to impaired mitochondrial complex I function,...

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Bibliographic Details
Main Authors: Georges N. Kanaan, Bianca Ichim, Lara Gharibeh, Wael Maharsy, David A. Patten, Jian Ying Xuan, Arkadiy Reunov, Philip Marshall, John Veinot, Keir Menzies, Mona Nemer, Mary-Ellen Harper
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717308066

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http://www.sciencedirect.com/science/article/pii/S2213231717308066

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