Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles

Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles

IntroductionEnhancer of zeste homolog 2 (Ezh2) is responsible for trimethylation of histone 3 at lysine 27 (H3K27me3), resulting in repression of gene expression. Here, we explore the role of Ezh2 in forebrain GABAergic interneuron development.MethodsWe removed Ezh2 in the MGE by generating Nkx2-1Cr...

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Bibliographic Details
Main Authors: Christopher T. Rhodes, Dhanya Asokumar, Mira Sohn, Shovan Naskar, Lielle Elisha, Parker Stevenson, Dongjin R. Lee, Yajun Zhang, Pedro P. Rocha, Ryan K. Dale, Soohyun Lee, Timothy J. Petros
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
interneurons
medial ganglionic eminence (MGE)
EZH2 (enhancer of zeste homolog 2)
epigenetics
neurodevelopment
single cell sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1334244/full

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https://www.frontiersin.org/articles/10.3389/fncel.2024.1334244/full

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