Microglia-derived TNF-α contributes to RVLM neuronal mitochondrial dysfunction via blocking the AMPK–Sirt3 pathway in stress-induced hypertension

Microglia-derived TNF-α contributes to RVLM neuronal mitochondrial dysfunction via blocking the AMPK–Sirt3 pathway in stress-induced hypertension

Abstract Background Neuroinflammation in the rostral ventrolateral medulla (RVLM) has been associated with the pathogenesis of stress-induced hypertension (SIH). Neuronal mitochondrial dysfunction is involved in many pathological and physiological processes. However, the impact of neuroinflammation...

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Bibliographic Details
Main Authors: Linping Wang, Tianfeng Liu, Xueping Wang, Lei Tong, Gaojun Chen, Shumin Zhou, Haili Zhang, Haisheng Liu, Wen Lu, Guohua Wang, Shuai Zhang, Dongshu Du
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Neuroinflammation
Subjects:
Microglia-derived TNF-α
Mitochondrial dysfunction
AMPK–Sirt3 pathway
Stress-induced hypertension
Online Access:https://doi.org/10.1186/s12974-023-02818-6

Internet

https://doi.org/10.1186/s12974-023-02818-6

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