CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

ABSTRACT Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex. We previously reported that NP is a monoubiquitinated protein which can be deubiquitinated by a cellular ubiquitin protease, USP...

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Bibliographic Details
Main Authors: Yu-Chen Lin, King-Song Jeng, Michael M. C. Lai
Format: Article
Language:English
Published: American Society for Microbiology 2017-07-01
Series:mBio
Subjects:
CNOT4
IAV
NP
RNA replication
influenza A virus
nucleoprotein
Online Access:https://journals.asm.org/doi/10.1128/mBio.00597-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00597-17

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