Expression of PD-1 mitigates phagocytic activities TAM in osteosarcoma

Expression of PD-1 mitigates phagocytic activities TAM in osteosarcoma

The high expression of programmed death 1 (PD-1) is a hallmark of T cell exhaustion, consequently inhibiting the anti-tumor immunity, tumor-associated macrophages (TAMs) aggravate Osteosarcoma (OS) progression. However, PD-1 expression on TAMs in OS metastasis remains unclear. Here, we used scRNA-Se...

Full description

Bibliographic Details
Main Authors: Chenhong Zheng, Heng Li, Xiaohui Zhao, Siyu Yang, Jinqin Zhan, Huaie Liu, Yan Jiang, Li shi, Yaxian Song, Yujie Lei, Tingdong Yu, Xiaoxiong Wang, Hongsheng Li, Xi Wang, Yushan Xu, Zhihong Yao
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Osteosarcoma
PD-1
Tumor-associated macrophages
Metastasis
scRNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023107067

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023107067

Similar Items