MecVax supplemented with CFA MEFA-II induces functional antibodies against 12 adhesins (CFA/I, CS1–CS7, CS12, CS14, CS17, and CS21) and 2 toxins (STa, LT) of enterotoxigenic Escherichia coli (ETEC)

MecVax supplemented with CFA MEFA-II induces functional antibodies against 12 adhesins (CFA/I, CS1–CS7, CS12, CS14, CS17, and CS21) and 2 toxins (STa, LT) of enterotoxigenic Escherichia coli (ETEC)

ABSTRACTEnterotoxigenic Escherichia coli (ETEC) strains that produce various adhesins and one or two enterotoxins are the leading causes of children’s diarrhea and travelers’ diarrhea. MecVax, a multivalent ETEC vaccine candidate, consists of two proteins, an adhesin multiepitope fusion antigen (MEF...

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Bibliographic Details
Main Authors: Chongyang Zhang, Siqi Li, Ipshita Upadhyay, Kathyrn L. Lauder, David A. Sack, Weiping Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
ETEC (enterotoxigenic E. coli)
diarrhea
vaccine
MecVax
CFA MEFA-II
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04153-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.04153-23

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