An increase in urinary primaquine and a reduction in urinary primaquine-5,6-orthoquinone in the Thai population with CYP2D6 reduced enzyme function

An increase in urinary primaquine and a reduction in urinary primaquine-5,6-orthoquinone in the Thai population with CYP2D6 reduced enzyme function

Objectives: Primaquine is metabolized by the cytochrome P450-2D6 enzyme (CYP2D6) to an active primaquine-5,6-orthoquinone (POQ). No relationships of CYP2D6 polymorphisms with the pharmacokinetics of primaquine and POQ were reported in the Thai population. Methods: We evaluated the genetic distributi...

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Bibliographic Details
Main Authors: Waritda Pookmanee, Siriwan Thongthip, Mathirut Mungthin, Chonlaphat Sukasem, Jeeranut Tankanitlert, Pajaree Chariyavilaskul, Supeecha Wittayalertpanya
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Primaquine
Primaquine-5,6-orthoquinone
CYP2D6
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024003827

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http://www.sciencedirect.com/science/article/pii/S2405844024003827

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