Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.

In the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium tuberculosis (Mtb) and constructed an Mtb mutant lacking the biotin biosynthetic enzyme 7,8-diaminopelargonic acid synthase, BioA. In biotin-free synthetic media, ΔbioA did not produce wild-type levels of...

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Bibliographic Details
Main Authors: Sae Woong Park, Marcus Klotzsche, Daniel J Wilson, Helena I Boshoff, Hyungjin Eoh, Ujjini Manjunatha, Antje Blumenthal, Kyu Rhee, Clifton E Barry, Courtney C Aldrich, Sabine Ehrt, Dirk Schnappinger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3182931?pdf=render

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http://europepmc.org/articles/PMC3182931?pdf=render

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