Population pharmacokinetics and model-based dosing evaluation of bedaquiline in multidrug-resistant tuberculosis patients

Population pharmacokinetics and model-based dosing evaluation of bedaquiline in multidrug-resistant tuberculosis patients

Aims: Bedaquiline is now recommended to all patients in the treatment of multidrug-resistant tuberculosis (MDR-TB) using standard dosing regimens. As the ability to measure blood drug concentrations is very limited, little is known about drug exposure and treatment outcome. Thus, this study aimed to...

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Bibliographic Details
Main Authors: Ge Shao, Ziwei Bao, Lina Davies Forsman, Jakob Paues, Jim Werngren, Katarina Niward, Thomas Schön, Judith Bruchfeld, Jan-Willem Alffenaar, Yi Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
bedaquiline
multidrug-resistant tuberculosis
population pharmacokinetic modeling
dosage evaluation
target attainment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1022090/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1022090/full

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