Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing

Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing

Abstract Background Early-onset renal cell carcinoma (eoRCC) is typically associated with pathogenic germline variants (PGVs) in RCC familial syndrome genes. However, most eoRCC patients lack PGVs in familial RCC genes and their genetic risk remains undefined. Methods Here, we analyzed biospecimens...

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Bibliographic Details
Main Authors: Elena V. Demidova, Ilya G. Serebriiskii, Ramilia Vlasenkova, Simon Kelow, Mark D. Andrake, Tiffiney R. Hartman, Tatiana Kent, James Virtucio, Gail L. Rosen, Richard T. Pomerantz, Roland L. Dunbrack, Erica A. Golemis, Michael J. Hall, David Y. T. Chen, Mary B. Daly, Sanjeevani Arora
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Genomics
Subjects:
Renal cancer
DNA replication
DNA repair
Germline
Online Access:https://doi.org/10.1186/s12864-023-09310-8

Internet

https://doi.org/10.1186/s12864-023-09310-8

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