Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection

Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection

We evaluated the immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters. Intranasal administration of BV-AdCoV-1 elicited strong humoral a...

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Bibliographic Details
Main Authors: Shen Wang, Long Xu, Ting Mu, Mian Qin, Ping Zhao, Liang Xie, Linsen Du, Yue Wu, Nicolas Legrand, Karine Mouchain, Guillaume Fichet, Yi Liu, Wenhao Yin, Jin Zhao, Min Ji, Bo Gong, Michel Klein, Ke Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chimpanzee Adenovirus Serotype 68
intranasal
COVID-19 vaccine
challenge study
golden Syrian hamsters
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.979641/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.979641/full

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