A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells
Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that i...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/09384 |