A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that i...

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Bibliographic Details
Main Authors: Heidi Hehnly, David Canton, Paula Bucko, Lorene K Langeberg, Leah Ogier, Irwin Gelman, L Fernando Santana, Linda Wordeman, John D Scott
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
protein kinase
signal transduction
cell regulation
mitotic spindle
testicular cancer
Online Access:https://elifesciences.org/articles/09384

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