The coenzyme B12 precursor 5,6-dimethylbenzimidazole is a flavin antagonist in Salmonella

The coenzyme B12 precursor 5,6-dimethylbenzimidazole is a flavin antagonist in Salmonella

Salmonella enterica subsp. enterica sv. Typhimurium str. LT2 (hereafter S. Typhimurium) synthesizes adenosylcobalamin (AdoCbl, CoB12) de novo only under anoxic conditions, but it can assemble the lower ligand loop (a.k.a. the nucleotide loop) and can form the unique C-Co bond present in CoB12 in the...

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Bibliographic Details
Main Authors: Lahiru Malalasekara, Jorge C. Escalante-Semerena
Format: Article
Language:English
Published: Shared Science Publishers OG 2023-08-01
Series:Microbial Cell
Subjects:
cobamide nucleobases
5,6-dimethylbenzimidazole
cob12 biosynthesis
benzimidazole antimicrobials
flavoenzyme inhibitors
Online Access:http://microbialcell.com/researcharticles/2023a-malalasekara-microbial-cell/

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http://microbialcell.com/researcharticles/2023a-malalasekara-microbial-cell/

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