Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection

Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection

Cell polarity is crucial for gastric mucosal barrier integrity and mainly regulated by polarity-regulating kinase partitioning-defective 1b (Par1b). During infection, the carcinogen Helicobacter pylori hijacks Par1b via the bacterial oncoprotein CagA leading to loss of cell polarity, but the precise...

Full description

Bibliographic Details
Main Authors: Irshad Sharafutdinov, Aileen Harrer, Mathias Müsken, Klemens Rottner, Heinrich Sticht, Christian Täger, Michael Naumann, Nicole Tegtmeyer, Steffen Backert
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Cell Insight
Subjects:
CagA
T4SS
Cortactin
Par1b
ZO-1
ASPP2
Online Access:http://www.sciencedirect.com/science/article/pii/S2772892724000166

Similar Items

Similar Items