The Interplay Between Tumor Suppressor p53 and Hypoxia Signaling Pathways in Cancer

The Interplay Between Tumor Suppressor p53 and Hypoxia Signaling Pathways in Cancer

Hypoxia is a hallmark of solid tumors and plays a critical role in different steps of tumor progression, including proliferation, survival, angiogenesis, metastasis, metabolic reprogramming, and stemness of cancer cells. Activation of the hypoxia-inducible factor (HIF) signaling plays a critical rol...

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Bibliographic Details
Main Authors: Cen Zhang, Juan Liu, Jianming Wang, Tianliang Zhang, Dandan Xu, Wenwei Hu, Zhaohui Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hypoxia
HIF
tumor suppressor
p53
mutant p53
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.648808/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.648808/full

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