Antibody–drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties

Antibody–drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties

Antibody–drug conjugates (ADCs) are used to target cancer cells by means of antibodies directed to tumor-associated antigens, causing the incorporation of a cytotoxic payload into target cells. Here, we characterized the mode of action of ADC costing of a TWEAKR-specific monoclonal antibody conjugat...

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Bibliographic Details
Main Authors: Anette Sommer, Sandra Berndt, Hans-Georg Lerchen, Sabrina Forveille, Allan Sauvat, Dominik Mumberg, Guido Kroemer, Oliver Kepp
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
immunogenic cell death
calreticulin
type i interferon response
adaptive immunity
ksp inhibitors
adcs
Online Access:http://dx.doi.org/10.1080/2162402X.2022.2037216

Internet

http://dx.doi.org/10.1080/2162402X.2022.2037216

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