Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa.

Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa.

PURPOSE:To examine the occurrence of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) following acute light damage in the naturally-occurring canine model of RHO-adRP (T4R RHO dog). METHODS:The left eyes of T4R RHO dogs were briefly light-exposed and retinas collected 3, 6 a...

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Bibliographic Details
Main Authors: Stefania Marsili, Sem Genini, Raghavi Sudharsan, Jeremy Gingrich, Gustavo D Aguirre, William A Beltran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0115723

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https://doi.org/10.1371/journal.pone.0115723

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