Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosis

Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosis

Summary: Transforming growth factor-β-activated kinase 1 (TAK1) is a central regulator of innate immunity, cell death, inflammation, and cellular homeostasis. Therefore, many pathogens carry TAK1 inhibitors (TAK1i). As a host strategy to counteract this, inhibition or deletion of TAK1 induces sponta...

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Bibliographic Details
Main Authors: R.K. Subbarao Malireddi, Ratnakar R. Bynigeri, Raghvendra Mall, Eswar Kumar Nadendla, Jon P. Connelly, Shondra M. Pruett-Miller, Thirumala-Devi Kanneganti
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Immunology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223010155

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223010155

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