The Impact of Surgery in IDH 1 Wild Type Glioblastoma in Relation With the MGMT Deregulation

The Impact of Surgery in IDH 1 Wild Type Glioblastoma in Relation With the MGMT Deregulation

Object: The treatment of choice in glioblastoma (GBM) is the maximal surgical extent of resection (EOR) followed by adjuvant chemo-radiotherapy. Furthermore, methylguanine-DNA methyltransferase (MGMT) promoter methylation is associated with prolonged overall survival (OS) and progression free surviv...

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Main Authors: Francesco Marchi, Nora Sahnane, Roberta Cerutti, Debora Cipriani, Jessica Barizzi, Federico Mattia Stefanini, Samantha Epistolio, Michele Cerati, Sergio Balbi, Luca Mazzucchelli, Fausto Sessa, Gianfranco Angelo Pesce, Michael Reinert, Milo Frattini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
extent of resection
MGMT
overall survival
progression free survival
temozolomide
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01569/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01569/full

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