Non-Linear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Cats

Non-Linear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Cats

The objective of this study was to develop a non-linear mixed-effects (NLME) model to describe the disposition kinetics of vitacoxib in cats following intravenous (I.V) and oral (P.O) (single and multiple) dosing. Data from six consecutive studies with 16 healthy neutered domestic short hair cats we...

Full description

Bibliographic Details
Main Authors: Jianzhong Wang, Benjamin K. Schneider, Hongzhi Xiao, Jicheng Qiu, Xiaohui Gong, Yeon-Jung Seo, Jing Li, Jonathan P. Mochel, Xingyuan Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Veterinary Science
Subjects:
Nlme
NSAIDs
PK/PD
vitacoxib
cats
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.554033/full

Internet

https://www.frontiersin.org/article/10.3389/fvets.2020.554033/full

Similar Items