Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept

Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept

Upregulation of hydrogen sulfide (H<sub>2</sub>S) biosynthesis, at least in part related to the upregulation of cystathionine β-synthetase (CBS) in cancer cells, serves as a tumor-promoting factor and has emerged as a possible molecular target for antitumor drug development. To facilitat...

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Bibliographic Details
Main Authors: Mark R. Hellmich, Celia Chao, Katalin Módis, Ye Ding, John R. Zatarain, Ketan Thanki, Manjit Maskey, Nadiya Druzhyna, Ashley A. Untereiner, Akbar Ahmad, Yu Xue, Haiying Chen, William K. Russell, Jianmei Wang, Jia Zhou, Csaba Szabo
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomolecules
Subjects:
hydrogen sulfide
anticancer
biomarker
prodrug
Online Access:https://www.mdpi.com/2218-273X/11/8/1073

Internet

https://www.mdpi.com/2218-273X/11/8/1073

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