What is the impact of mRNA 5’ TL heterogeneity on translational start site selection and the mammalian cellular phenotype?
A major determinant in the efficiency of ribosome loading onto mRNAs is the 5’ TL (transcript leader or 5’UTR). In addition, elements within this region also impact on start site selection demonstrating that it can modulate the protein readout at both quantitative and qualitative levels. With the in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00156/full |