Intranasal inoculation of female BALB/c mice with replication-deficient human adenovirus type 5 expressing SARS-CoV‐2 nucleocapsid protein aggravates lung pathology upon re-encountering the antigen

Preclinical studies indicate that SARS-CoV-2 nucleocapsid (N)-based vaccines, along with other viral protein(s), confer protection in various animal models against infection by SARS-CoV-2 ancestral virus and variants of concern. However, the optimal vaccination procedure and the role of N-specific h...

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Bibliographic Details
Main Authors: Junxia Cao, Hongjing Gu, Xueting Zhang, Hongfang Yun, Jiarong Li, Chuan-Yimu Si, Jiyan Zhang, Hui Wang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Virus Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170223001636