Direct actions of dapagliflozin and interactions with LCZ696 and spironolactone on cardiac fibroblasts of patients with heart failure and reduced ejection fraction

Direct actions of dapagliflozin and interactions with LCZ696 and spironolactone on cardiac fibroblasts of patients with heart failure and reduced ejection fraction

Abstract Aims Inhibitors of SGLT2 (SGLT2i) have shown a positive impact in patients with chronic heart failure and reduced ejection fraction (HFrEF). Nonetheless, the direct effects of SGLT2i on cardiac cells and how their association with main drugs used for HFrEF affect the behaviour and signallin...

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Bibliographic Details
Main Authors: Luis Ortega‐Paz, Helena Cristóbal, José Tomás Ortiz‐Perez, Pablo García de Frutos, Guiomar Mendieta, Elena Sandoval, Juan José Rodriguez, Emilio Ortega, Ana García‐Álvarez, Salvatore Brugaletta, Manel Sabaté, Ana Paula Dantas
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:ESC Heart Failure
Subjects:
Systolic heart failure
Sodium‐glucose cotransporter‐2 inhibitors
Dapagliflozin
Sacubitril‐valsartan
Spironolactone
Pharmacology
Online Access:https://doi.org/10.1002/ehf2.14186

Internet

https://doi.org/10.1002/ehf2.14186

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