Inhibition of specific signaling pathways rather than epigenetic silencing of effector genes is the leading mechanism of innate tolerance

Inhibition of specific signaling pathways rather than epigenetic silencing of effector genes is the leading mechanism of innate tolerance

IntroductionMacrophages activated through a pattern-recognition receptor (PRR) enter a transient state of tolerance characterized by diminished responsiveness to restimulation of the same receptor. Signaling-based and epigenetic mechanisms are invoked to explain this innate tolerance. However, these...

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Bibliographic Details
Main Authors: Anna M. Masyutina, Polina V. Maximchik, Georgy Z. Chkadua, Mikhail V. Pashenkov
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
innate immune response
tolerance
lipopolysaccharide
TLR4
muramyl peptides
NOD1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1006002/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1006002/full

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