Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer

Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer

Abstract Background Fungi are important sources for bioactive compounds that find their applications in many important sectors like in the pharma-, food- or agricultural industries. In an environmental monitoring project for fungi involved in soil nitrogen cycling we also isolated Cephalotrichum gor...

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Main Authors: Andreas Schüller, Lena Studt-Reinhold, Harald Berger, Lucia Silvestrini, Roman Labuda, Ulrich Güldener, Markus Gorfer, Markus Bacher, Maria Doppler, Erika Gasparotto, Arianna Gattesco, Michael Sulyok, Joseph Strauss
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Fungal Biology and Biotechnology
Subjects:
Secondary metabolism
Cephalotrichum
Doratomyces NG_p51
Rasfonin
Transcriptome analysis
Genome analysis
Online Access:https://doi.org/10.1186/s40694-023-00158-x

Internet

https://doi.org/10.1186/s40694-023-00158-x

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